臨床小児科: オープンアクセス
オープンアクセス

概要

Clinical and Laboratory Approach of Urinary Tract Infection in Infants

Haia Nasser, Ehsan N, Suzan N, Sharon Sigal,Sapir Goldshtein, Jerdev Michael, Boshra Nasser ,Wael Nasser

Introduction: Urinary Tract Infection (UTI) in neonates (<30 days of age) is related to bacteremia and congenital malformations of the kidneys and the urinary system. Upper urinary tract infections cause pyelonephritis, which may lead to scaring of the renal parenchyma and eventually to chronic renal disease. In neonates that were born, the prevalence of UTI ranges from 7% to 15% in different studies. The risk of UTI is higher among prematures and low birth weight neonates. In this study we examine closely the microbiological properties and symptoms of primary infection in young infants with predisposition to recurrent infection.

Methods: Our study is a retrospective study that included infants with urinary tract infection in the first year of life, 222 infants were hospitalized during 2011-2016.

Results: 222 infants were enrolled; (35%) of the infants treated were <2 months old. Infants with urinary tract infection (20%) recurrent infections were seen. Laboratory findings have shown that the E-coli bacterium is the main contaminant. And further Klebsiella, Enterococcus, Proteus mirabilis. Note that in terms of susceptibility Klebsiella and E-coli bacteria showed high sensitivity to cephalospirins, resprim and 70% to tazobactam. Resistant bacteria such as Klebsiella and ESBL are shown to be susceptible to tzobactam, and aminoglycosides especially amikacin and garamycin in 20%-30% especially in infants with recurrent urinary tract infections in the first year. Noting the common contaminating bacteria are E-coli and Klebsiella, and in the recurrent infections these bacteria were observed more resistance especially to aminoglycosides and Tazocin.