自閉症 - オープンアクセス
オープンアクセス

概要

Is Valacyclovir a Mood Stabilizer?

Theodore A Henderson

Growing evidence indicates the role of viral agents in neuropsychiatric conditions, such as chronic fatigue syndrome (CFS), Alzheimer’s disease, and possibly autism. This case report describes a patient who was afflicted with treatment-resistant childhood bipolar disorder, who also had features associated with attention deficit hyperactivity disorder and autism spectrum disorder. After failing multiple regimens for mood stabilization (anticonvulsants, lithium, neuroleptics), a trial of valacyclovir was initiated. The decision to use an antiviral agent was based on the patient’s laboratory data and the marked treatment response of the patient’s sibling, who manifested symptoms of depression and CFS. The patient in this report showed a dramatic improvement in his volatile mood, irritability, concentration, social reciprocity, and overall personality. He was maintained on valacyclovir at 1000 mg BID, while the doses of the mood stabilizing agents and stimulants were reduced by as much as 50%. After 37 months of ongoing valacyclovir treatment, the patient continues to make improvements and is being mainstreamed in school. The case illustrates a potential role of viruses in neuropsychiatric and psychiatric disorders and the potential benefit of antiviral therapy in treatment-refractory cases.