遺伝症候群と遺伝子治療のジャーナル
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概要

Recent Advances in Autoinflammatory Diseases and Animal Models

Sigrun R. Hofmann, Michael C. Heymann, Anne Hermsdorf and Angela Roesen-Wolff

Autoinflammatory disorders are a fast growing group of human diseases which have provided unique insights into key mechanisms of inflammatory pathways. With the recognition of inflammasomes as an important factor in causing ongoing inflammatory responses, the innate immune system experienced a renaissance in the field of immunological research. Here we summarize recent advances in the understanding of the pathogenesis of autoinflammatory diseases and review selected mouse models available to study such diseases.