がん研究と免疫腫瘍学ジャーナル
オープンアクセス

概要

An Evaluation of the Plasma Free Amino Acid Profile Level and Ultrasound Elastography Data of Patients with Fibromyalgia

Ezgi Temel Avsar*, Kudret Cem Karayol, Sunay Sibel Karayol, Ismail Koyuncu

Objectives: The aim of this study was to clarify the relationship of the pathogenesis of widespread pain and the measured levels of plasma free amino acids in patients with fibromyalgia syndrome, and to evaluate the relationship with symptom severity. It was also aimed to examine the effect of plasma amino acid profile levels on muscle elasticity by evaluating potential tissue changes in trapezius and rhomboid muscles with ultrasound elastography.

Patients and methods: Fifty female patients with FMS and 47 healthy women were included in the study. The severity of pain was measured with a Visual Analog Scale, and the patients completed the Fibromyalgia Impact Questionnaire to determine functional status. Blood samples were taken from all the patients and control subjects. All groups were evaluated with ultrasound elastography.

Results: The plasma cysteine, glutamine, glycine, serine, ethanolamine, norvaline and argininosuccinic acid levels were determined to be statistically significant higher in the patient group than in the control group. The anserine, ortho-phosphorylethanolamine, and cystathionine levels were determined to be statistically significantly lower in the patient group than in the control group. The right and left rhomboid major muscles stiffness of the patient group were found to be statistically significantly higher than those of the control group.

Conclusion: In conclusion, some amino acid levels, there could be a relationship between the amino acid changes and pain severity. There was found to be increased stiffness in the rhomboid muscles of the FMS patients compared to the healthy control group.