周術期医学ジャーナル
オープンアクセス

概要

Cell Therapy in Transplantation

Aliakbar Amirzargar*, Amir Hossein Mansourabadi, Sara Bahramkiya

Organ transplantation is an established and practical definitive treatment option for patients with end-stage organ dysfunction. Unlike improvements in short-term graft survival, long-term graft survival is the main challenge due to the increased morbidity and mortality associated with the toxicity of immunosuppressive regimens and chronic rejection. Since a novel therapeutic strategy to fulfill allograft tolerance seems urgent, the attention of the transplant community is focusing on the development of the new safe approach to prolong graft survival. Various researches have focused on immune regulation in the context of organ transplantation with mesenchymal stem cells and regulatory T cells (Tregs) identified as cells that have the potential to suppress or optimize the immune responses in different situations. In this review article, we will provide an overview of human Tregs and different kinds of promising cells in the field of immune-suppressing, their phenotypic and functional characterization. Furthermore, we will review the different experiences of the clinical application of immunomodulatory cells in the setting of solid organ transplantation.