有機化学: 現在の研究
オープンアクセス

概要

経路標的化合物の同定および薬物間相互作用の予測方法としての化学修飾子スクリーニング

西谷尚之

Screenings for genetic modifiers, such as suppressors or enhancers, in model organisms have identified and characterized important signaling pathways. Likewise, a phenotype induced by a chemical compound can be suppressed or enhanced by another compound. Here, I introduce chemical modifier screenings as phenotype-based assays that expand therapeutic targets to unexpected molecules and that facilitate identification of target signaling pathways. Also, chemical modifier screening can be applied to predicting possible drug-drug interactions that cause adverse effects.