応用薬学ジャーナル
オープンアクセス

概要

DESIGN, SYNTHESIS, CHARACTERIZATION AND ANTIMICROBIAL EVALUATION OF NEW PYRAZOLINE-5-ONES

Krishna Naik, Aluru Raghavendra Guru Prasad, Yadati Narasimha Spoorthy, Lakshmana Rao Krishna Rao Ravindranath

Purpose: To synthesise, charecterise phenyl hydrazones namely, {4-[3-methyl-5-oxo-4- (phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid N|-(4-substitutedthiazole- 2-yl)-hydrazide VII and to evaluate the antibacrial activity. Methods: The synthesis of title compounds has been schemed elaborately and the structures of the compounds were established by elemental analysis, IR, 1H NMR and mass spectra. The antibacterial activity of the title compounds were evaluated against Staphylococcus aureus NCCS 2079 and Bacillus cereus NCCS 2106, Escherichia coli NCCS 265 and Pseudomonas aeruginosa NCCS 2200 and antifungal activity evaluated against Aspergillus niger NCCS 1196, Candida albicans NCCS 2106 by disk diffusion method. Results: The screened data reveal that the studied phenyl hydrazones under study exhibited promising antimicrobial activity against all the tested microbes. The antimicrobial activity of title compounds were compared with that of standadards. The title compounds with pnitrophenyl, p-chlorophenyl, p-bromophenyl were more active agaist bacteria, where as the compounds with substituents namely phenyl, p-tolyl, p-anisyl, p-hydroxyphenyl, pnitrophenyl were more active against fungi than the other compounds under investigation. Conclusion: Among the ten novel phenyl hydrazones synthesised {4-[3-methyl-5-oxo-4- (phenyl hydrazono)-4,5-dihydro-pyrazol-1-yl]-phenoxy}-acetic acid N|-(4-(4-nitrophenyl)- thiazole-2-yl)-hydrazide was found the most active than the others. The other compounds demonstrated moderate activity against the tested microorganisms.