応用薬学ジャーナル
オープンアクセス

概要

Editorial Note on: Unfolded protein response of Mitochandria: A novel pathway in metabolism and immunity

Pushpa B

Mitochondrial unfolded protein reaction (UPRmt) is a cell stress reaction identified with the mitochondria. The UPRmt results from unfolded or misfolded proteins in mitochondria past the limit of chaperone proteins to deal with them.The UPRmt can happen either in the mitochondrial network or in the mitochondrial internal membrane. In the UPRmt, the mitochondrion will either upregulate chaperone proteins or summon proteases to corrupt proteins that neglect to crease properly.UPRmt causes the sirtuin SIRT3 to enact cancer prevention agent chemicals and mitophagy.