遺伝症候群と遺伝子治療のジャーナル
オープンアクセス

概要

Eosinophils and Airway Inflammation

Armengot M, Garin L, Peiro T, Milara J and Cortijo J

Respiratory diseases which are associated with the presence of eosinophilia include: asthma, rhinitis, chronic rhinosinusitis, nasal polyposis, ASA triad (Acetil Salicilic (aspirin) ASA triad: nasal polyposis, asthma, and nonsteroid anti-inflammatory analgesic intolerance), fungal airway infections and systematic self-immune vasculitis (Churg-Strauss syndrome). The airway inflammation mediated by eosinophils appears in a metachronous form in the superior and inferior airways during the chronic phase of the disease. The association between asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) is more frequent in patients with higher tissue eosinophilia and the disease is more severe, both in the upper and lower airways. Moreover, a high degree of eosinophilia is associated with a favorable response to corticosteroid treatment. The purpose of this work is to review the relation between eosinophils and airway respiratory diseases, as well as their clinical consequences.