select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='33742' and ad.lang_id='6' and j.lang_id='6' and vi.lang_id='6' Evaluation of Molecular Diversity of Mycobacterium tuberculo | 33742
抗酸菌症

抗酸菌症
オープンアクセス

ISSN: 2161-1068

概要

Evaluation of Molecular Diversity of Mycobacterium tuberculosis Strains By Polymorphisms in RD Regions

Ehsan Sharifipour, Mohammad Javad Nasiri, Parissa Farnia, Mohadeseh Mozafari, Shiva Irani and Ali Akbar Velayati

Background: The region of differences (RDs) polymorphisms is a potential molecular epidemiology method to distinguish origins of Mycobacterium tuberculosis (MTB). Till date, 68 RDs were identified in MTB. This study was designed to investigate highly polymorphic regions (RD1, RD150 and RD181) among MTB strains isolates from Iranian Pulmonary tuberculosis patients (PTB).

Method and materials: A total of the 190 MTB isolates were identified by conventional and molecular methods. Thereafter, Spoligotyping and RD typing (RD1, RD150 and RD181) were applied to genotype these strains.

Results: The most frequent spoligotype belong to Haarlem (n=72, 37.8%) followed by CAS (n=37, 19.4%), T1 (n=18, 9.4%) and Beijing (n=11, 5.7%) lineages. Deletion in RD181 was only identified among Beijing lineage.

Conclusion: Deletion in RD181 was prominent among the prevalent Beijing strains in Iran. In this regard, this deletion marker can be used in identification, phylogeny, and molecular epidemiology of the Beijing genotype.

免責事項: この要約は人工知能ツールを使用して翻訳されたものであり、まだレビューまたは検証されていません。
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