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概要

Hepatoprotective Efficacy of Gold Nanoparticle Synthesized by Green Method Using Trigonella Foenum-Graecum Seed Extract

Sourav Ghosh, Antony Gomes*

Earlier study showed the effective hematopoietic potential of gold nanoparticle (FG-GNP) synthesized using fenugreek seed aqueous extract. The present work was an effort to establish the hepatoprotective activity of FG-GNP in animal model. Swiss albino male mice (n=4) were grouped into: Gr.1- Sham Control, Gr.2- CCl4 treated (1.5ml/kg), Gr.3- Standard Drug (Silymarin) treated (100mg/kg/p.o.), Gr.4- Fenugreek treated (100mg/kg/p.o.), Gr.5- FG-GNP treated (0.5mg/kg/p.o.). Biochemical parameters (AST, ALT, γGT, ACP, ALP, total bilirubin), pro-inflammatory parameters (IL 1β, IL 17, TNF α), anti-inflammatory parameters (IL 10, Cathepsin K), antioxidant parameters (GSH, SOD, Catalase) and prooxidant parameter (LPO) were assayed. Histology of liver tissue was done. AST and ALT release from liver tissue was done by in vitro liver slice model. Statistical analysis was done by one way ANOVA, values expressed as mean±SE, PFG. Further studies regarding molecular actions of FG-GNP are warranted.