select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='50343' and ad.lang_id='6' and j.lang_id='6' and vi.lang_id='6'
ISSN: 2155-9899
Bhaskari J and Lakshmi Krishnamoorthy
In a study analysing the plasma and ascitic fluid levels of VEGF-A in 220 epithelial ovarian cancer patients, we found that the patients presenting with markedly elevated levels of VEGF-A in their ascitis fluid came back with disease recurrence within 2 years post primary line of treatment. VEGF-A levels in the ascites of patients was a better marker for prognosis and aggressive disease compared to plasma VEGF-A levels. Although, plasma VEGF-A levels did not associate with recurrence, it did associate with other clinico-pathological factors studied as the stage, grade, CA-125 levels and the serous histopathology. VEGF-A plasma levels did not correlate with increased production of ascites but increased VEGF-A levels in the ascites correlated with aggressive disease, recurrence and mortality. The results of our study show that while the measurement of plasma VEGF-A levels may be a biomarker for malignant disease, levels of VEGF-A in ascitic fluid was a strong predictive marker for poor prognosis and rapid recurrence.