内科: オープンアクセス
オープンアクセス

概要

Impact of Hyperuricemia on the Prognosis in Patients with Acute Myocardial Infarction and Atrial Fibrillation

Sil-Dong Guo

Background: Hyperuricemia (HUA) is associated with poor prognosis in patients with Acute Myocardial Infarction (AMI). However, its prognostic value in patients with AMI and coexisting Atrial Fibrillation (AF) is not clear.

Methods: We retrospectively studied patients admitted to three hospitals in Beijing, China with the diagnoses of both AMI and AF at discharge/death. HUA was defined as serum uric acid levels ≥ 6.8 mg/dl. The endpoint of the study was in-hospital all-cause mortality. The relationship between HUA and the endpoint was analyzed by multivariate logistic regression. Subgroup analyses were done in patients categorized by sex and in those who underwent Coronary Angio Graphy (CAG).

Results: After excluding those with missing data, a total of 651 patients were included in the study with the median age of 76 and 40.25% were women. Patients with HUA counted up to 40.40% of the study population and 15.51% of the patients died during hospitalization. HUA was shown to be an independent predictor of in-hospital mortality after adjusting for confounding factors (Adjusted Odds Ratio (OR) 2.09, 95% Confidence Interval (CI) 1.29-3.40, p=0.003). Subgroup analysis categorized by sex showed similar results for HUA in male patients (Adjusted OR 2.02, 95% CI 1.04-3.95, p=0.039) but not in female patients. HUA was also not included in the final adjusted model in patients who underwent CAG.

Conclusion: HUA was an independent predictor of in-hospital all-cause mortality in patients with AMI and coexisting AF. Similar conclusion could be drawn in male patients but not in female patients and patients who underwent CAG.