select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='48017' and ad.lang_id='6' and j.lang_id='6' and vi.lang_id='6' Liver-Mediated Myocardial Protection in Experimental Myocard | 48017
プロバイオティクスと健康に関するジャーナル

プロバイオティクスと健康に関するジャーナル
オープンアクセス

ISSN: 2155-9880

概要

Liver-Mediated Myocardial Protection in Experimental Myocardial Infarction

Shu Q. Liu, Brandon J. Tefft and Bo Dong

Myocardial ischemia activates innate cardioprotective mechanisms, including expression of growth factors, activation of cardiac resident stem cells and mobilization of bone marrow cells to the ischemic myocardium, which alleviate ischemic injury and promote cardiomyocyte regeneration. This review addresses a newly recognized cardioprotective mechanism involving the liver. Myocardial ischemia induces liver responses, including mobilization of hepatic cells to the circulatory system and upregulation of hepatic secretory proteins, such as fibroblast growth factor 21 (FGF21) and trefoil factor 3 (TFF3). The mobilized hepatic cells either engraft to the ischemic myocardium or disintegrate in the circulatory system, facilitating delivery of the hepatic secretory proteins. These proteins contribute to myocardial protection, alleviating myocardial infarction. These investigations provide new information for understanding the innate cardioprotective mechanisms and developing therapeutic strategies for myocardial infarction.

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