There are three important factors for translational medicine; vision, environment and idea. We must know what we want to do, why we want to do, and for whom we want to do. In Kyushu island of Japan, I saw many human T-leukemia virus type 1 (HTLV-1)-infected carriers and adult T-cell leukemia (ATL) patients. This is the reason why I decided to do something to help them. We can meet with the best colleagues and important themes of our work in a certain place. Good collaborators could help us to achieve our projects. Such a good relationship activates our performance. Only a few HTLV-1 carriers develop to ATL after a long latent period. It is suggested that there is unique oncogenic mechanism in human, especially immune system in elderly. We have a responsibility to find out important elements composing diseases in vivo.