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Nano Pharmaceuticals 2019: Transdermal drug delivery system - Fremiot J Mascarenhas - Bhavnagar Medical Association

Fremiot J Mascarenhas

Transdermal drug delivery refers to a system in which a fixed amount of drug is delivered across the skin over a period of time to the bloodstream so as to maintain a therapeutic level of that drug. This method of drug delivery is painless and has excellent compliance in both pediatric and geriatric age bracket because it is pain-free and hassle free and doesn't need any specialized equipment for its use. Transdermal method of drug delivery features a great many advantages over other conventional routes of drug administration like oral, intramuscular, intravenous. Medication applied in form of a fixed-dose adhesive patch that is applied to the skin surface and is absorbed through the pores of the skin and delivered in the bloodstream in a controlled way. The main objective of this painless route of administering a drug is to supply a therapeutic dose level of drug within the bloodstream with the minimal patient to patient variation while limiting the side effects if the same were to be administered by any other route.

A skin patch may be a medicated adhesive patch that's placed on the skin to deliver a selected dose of medication through the skin and into the bloodstream. Often, this promotes therapeutic to an injured part of the body. An advantage of a transdermal drug delivery route over other sorts of medication delivery like oral, topical, intravenous, intramuscular, etc. is that the scrap provides a controlled discharge of the medication into the patient, typically through either a permeable membrane covering a reservoir of medication or through body heat melting lean layers of medication embedded in the adhesive. Transdermal drug delivery offers controlled discharge of the drug into the patient, it enables a light blood level profile, leading to compact systemic side effects and, sometimes, enhanced efficiency over other amount forms. The main objective of transdermal drug delivery system is to deliver drugs into circulation through skin at programmed rate with minimal inter and intrapatient variations.