臨床および実験皮膚科学研究ジャーナル
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概要

Note on Benefits of Retinoid for Skin

Kenneth Jones

Retinoids reduce fine lines and wrinkles by increasing the production of collagen. They also stimulate the assembly of new blood vessels in the skin that improves skin colour. Additional benefits include fading age spots and softening rough patches of skin. Vitamin A and its derivatives, notably retinol slows both chronological and photo-induced aging processes. Retinol reduces the appearance of wrinkles and therefore they decrease the skin firmness and elasticity property by protective against scleroprotein and elastin fiber changes [1]. Additionally to retinol’s rejuvenating skin advantages through direct transcriptional activation, recent study suggest an epigenetic regulation through micro-RNAs (miRNAs) modulation. We investigated how retinol supports the stimulation of Type I scleroprotein and elastin through proteomic, transcriptomic and epigenetic miRNA-expression changes in human skin fibroblasts. Acne may be a complex skin condition, characterized by proliferation of bacterium, hyper keratinization, inflammation, and excess secretion production. Acne sufferers want to address all aspects of their acne, including the disease initial state of the lesions and cosmetic complexion issues, such as marks, tone, and redness. One first-line topical treatment for mild to moderate skin acne that dermatologists suggest is a combination of Benzoyl Peroxide (BPO), to target the bacteria, and a retinoid, to promote surface cell turnover