泌尿器科・外科
オープンアクセス
ISSN: 2168-9857
ISSN: 2168-9857
Minhua Qiu, Ting Zhang, Jibing Chen, Hongjun Gao
Objective: To evaluate the effect of Tamsulosin combined with self-prepared diuretic stone removal decoction on postoperative stone removal rate and recurrence rate of patients with upper urinary tract stones.
Methods: From October 2021 to October 2022, 93 patients in the inpatient department of Urology Department of Ruikang Hospital Affiliated to Guangxi University of Chinese Medicine who were treated for upper urinary tract stones were selected as the study objects. During the study, 2 patients lost follow-up and 4 refused to continue taking Chinese medicine, and 87 patients completed the study. The patients were randomly divided into three groups by random number table method. Group A was treated with Tamsulosin hydrochloride sustained-release capsule, group B was treated with our hospital's self-prepared diuretic stone drainage decoction, and group C was treated with Tamsulosin hydrochloride sustained-release capsule combined with self-prepared diuretic stone drainage decoction. After 4 weeks of treatment, imaging, blood leukocytes, urinary occult blood, serum creatinine, hematuria, TCM syndrome score, pain score, stone recurrence and other indicators of the three groups were detected, and follow-up was conducted. The discharge of residual stone fragments and the recurrence rate after taking the drug were counted, and the clinical efficacy of the three groups was compared.
Results: After 4 weeks of treatment, serum creatinine was significantly improved in all three groups (P<0.05); Comparison between groups A and B showed similar efficacy (P>0.05), the curative effect of group C was better than that of groups A and B (P<0.05). There was no significant change in uric acid in the three groups before and after treatment (P<0.05). Urinary occult blood improved significantly among the three groups after 2 weeks of treatment (P>0.05), the difference between group B and C and group A was statistically significant (P<0.05), and there was no significant difference between groups B and C (P>0.05). However, there was no significant difference between the three groups after 4 weeks of treatment (P>0.05). In terms of inflammatory indicators, after 4 weeks of treatment, the blood leukocytes in all three groups decreased (P<0.05), the effect of group C was better than that of groups A and B (P<0.05). In terms of pain score, after 4 weeks of treatment, the pain in all three groups was less than before (P<0.05), and group C had the best effect, followed by group B, both of which were better than group A. The total effective rate of stone removal in group A is 76.67%, the total effective rate of stone removal in group B is 78.57%, and the total effective rate of stone removal in group C is 93.10%. After comparison, the curative effect of group A and group B is comparable (P>0.05), group C was better than groups A and B (P<0.05). In this study, the recurrence rate of stone was 676 in group A, 3.57% in group B, and no recurrence in group C after 3 months of treatment.
Conclusion: These results indicated that Tamsulosin hydrochloride sustained release capsule combined with self-designed diuretic stone removal decoction could reduce the level of blood creatinine, quickly relieve urinary occult blood, effectively reduce inflammatory factors, reduce the risk of postoperative infection, relieve postoperative pain, improve postoperative stone removal rate and reduce the recurrence rate.