有機化学: 現在の研究
オープンアクセス

概要

On the Mechano-Chemiosmotic Mechanism of Action of Guanidinies on Functional Activity of Mitochondria and Aging

Eldar A Kasumov, Ruslan E Kasumov and Irina V Kasumova

Functional activity of mitochondria in the cell is fully regulated by a complex mixture of dissolved in water substances of the cytosol compound. The concentrations of these substances are different, which is important in processes such as osmoregulation and signaling both of a cell and of mitochondria for ATP synthesis. We studied the action of guanidine on the functional activity of mitochondria. Mitochondria showed a trend to inhibition of oxidative phosphorylation in the presence of different guanidine concentrations. Also, an oscillatory volume changes shrinkage-swelling of mitochondria ¬- are largely abolished and pH changes of incubation medium in addition of ADP are inhibited in the presence of guanidine ion. The mechanism of inhibition of these processes is explained by mechano-chemiosmotic model. In the article, it is discussed that a disruption of the movement of calcium ions (which are moved cyclically between the external environment (cytosol), the matrix and intermembrane space) by various agents, including guanidine leads to disruption of ATP synthesis. We conclude that the L-arginine (2-Amino-5-guanidinopentanoic acid) deficiency in a body leads to a decrease in energy production and, also, it is the cause of aging, type 2 diabetes, cancer and other diseases.