クローニングと遺伝子導入
オープンアクセス

概要

PVT1: A Cancer-associated Non-coding Gene Revisited

Takashi Sonoki

PVT1 was originally identified as a transcriptional unit from a human homologous sequence to Pvt1, which was cloned from murine plasmacytoma with t(6;15). Previous studies have revealed various genetic alterations in the PVT1 locus, including chromosome translocation, amplification, chromothripsis, and single nucleotide polymorphisms in human diseases, suggesting important roles of PVT1 in the pathogenesis. However, because this locus does not produce protein coding sequences, its functional properties have not been characterized and its biological significance remains unclear. Recent studies have shown that the PVT1 locus encodes lincRNAs and microRNAs. Therefore, current investigations are being performed focusing on the biological features of this long-standing puzzle gene as a non-coding gene.