ISSN: 2471-9315
ネーハ シャルマ、パラス シン、モニカ マリク、サンギータ シャルマ、ハリド U. カイヤム、ラビンドラ クマール ディーワン、ニーラジ クマール
Tuberculosis (TB) is known to cause the highest number of infection related deaths worldwide. In 2016, WHO approved TB-LAMP (Loop-Mediated Isothermal Amplification) assay as a replacement for smear microscopy for the diagnosis of PTB in adult TB suspects. However, more epidemiological research should be conducted to support the deployment of the TB-LAMP program in peripheral level healthcare settings. This study analyzed the diagnostic efficacy of rapid and inexpensive TB-LAMP assay for the diagnosis of PTB. TB-LAMP assay displayed 1.8-fold (minimum 49.2%) higher positivity rates than the smear microscopy test (maximum 29.6%). In comparison to the composite reference standard, TB-LAMP assay was observed to be 84.3% sensitive and 96.8% specific for the diagnosis of PTB. The positive predictive value and negative predictive value of the TB-LAMP assay were 88.2 (95%CI: 77.3-94.3) and 95.6 (95% CI: 94.2-96.7), respectively. Therefore, TB-LAMP assay should be an essential point of care test for the diagnosis of PTB in adults, especially in resource limited and rural healthcare settings of TB endemic regions.