応用薬学ジャーナル
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概要

Spectrophotometric Determination of Atorvastatin Calcium and Rosuvastatin Calcium in Bulk and Dosage Form Using P-Dimethylaminobenzaldehyde

Sobhy M. Al-Adl, Lobna M. Abdel-Aziz and Maha AM. Mohamed

A simple and sensitive spectrophotometric method is described for determination of atorvastatin calcium and rosuvastatin calcium in bulk and tablet forms. The method depends on the formation of colored chromogen between atorvastatin calcium and rosuvastatin calcium and p-dimethylaminobenzaldehyde (PDMAB) in acidic conditions and the reaction mixture exhibits maximum absorbance at λmax 540 and 570 nm for atorvastatin calcium and rosuvastatin calcium, respectively. Under the indicated conditions, this method was linear over the concentration range of 20-160 μg/ml and 2-16 μg/ml for atorvastatin calcium and rosuvastatin calcium, respectively. The method was statistically applied for the determination of drugs in both bulk and tablet forms. Results were compared with reference methods and no significant difference was obtained.