臨床小児科: オープンアクセス
オープンアクセス

概要

Staph Hominis in Overlapping Presentation of MIS-C, Kawasaki-LikeSyndrome, and Toxic-Shock-Syndrome in COVID-19 PCR Negative Child

Suliman Elwagei Ahmed*, Ahmed Mohamed Galbat, Fathelrhman Ahmed Ali

Background: Multisystem Inflammatory Syndrome in Children (MIS-C) is a serious condition in which some parts of the body including the heart, blood vessels and other systems become inflamed. Inflammation typically includes swelling, often with redness and pain. Many, but not all, children with MIS-C test negative for a current infection with the virus that causes COVID-19. Often toxic shock syndrome can manifest with a similar presentation in children, which usually results from toxins produced by Staphylococcus aureus. We present the case of 10-year old boy tested negative COVID-19 twice, and presented to our Pediatrics-ER with high grade fever, generalized body rash, loose motion, cough, and poor oral intake for 2 days. Case Report: 10 years old boy who had been tested negative for SARS-CoV-2 infection, was presented with his mother (who’s a nurse in a clinic) to the ER with high grade fever, generalized body erythema, and erythematous macular rash. He also had cough, loose motion, and poor oral intake for the last 2 days. A real-time polymerase chain reaction test was negative for the second time, and blood culture identified staph Hominis, dividing the underlying etiology into two differentials. Conclusions: The etiology of MIS-C/Kawasaki-Like-Syndrome is unclear, a likely hypothesis of an infectious agent as a trigger for inflammatory reaction, among those agents are Staphylococcus, and Corona-Virus. The MIS-C is a life threatening condition, and delaying of IVIG administering is fatal, Coronary Aneurysm could end with. MIS-C presentation could resemble TSS caused by Staphy Hominis, particularly in those who at risk of contracting (HAI) hospital acquired infections. Further studies shall be conducted on the role of such normal skin flora could play in triggering MIS-C in children who are genuinely COVID-19 negative, since a follow up contact, 4 weeks post discharge revealed a negative result of the child’s COVID-19 Ig-G Antibody Serology Test.