植物生化学および生理学ジャーナル
オープンアクセス

概要

The Effect of a Preoperative Single Dose of Magnesium Sulfate versus Preoperative Ultrasound Guided Bilateral Transversus Abdominis Plane Block on Hemodynamics and Postoperative Analgesic Requirements in Patients Undergoing Colorectal Surgery

Sabry Mohamed Amin and Rabab Mohamed Mohamed

Background: The transversus abdominis plane (TAP) block is a peripheral nerve block, utilized to anesthetize the sensory nerves by local anesthetic injection in the neurovascular plane. Magnesium sulfate can prevent the induction of central sensitization from peripheral nociceptive stimuli at the spinal action site by blocking N-methyl-Daspartate (NMDA) receptors. The aim of our study is to compare the effect of preoperative single-dose of Magnesium sulfate versus preoperative ultrasound guided bilateral transversus abdominis plane block on hemodynamics, and postoperative analgesia in patients undergoing colorectal surgical operations. Patients and methods: This study was conducted on 40 adult patients ASA I and II scheduled for colorectal surgical operations under general anesthesia. The patients were randomly divided into two equal groups as follow: Group I: Patients received magnesium sulfate 50 mg/kg IV as single-dose before induction of anesthesia. Group II: Bilaterally TAP block was performed before induction of anesthesia under ultrasound guidance. In both groups, general anesthesia was used. Measurements: HR and MABP, Intraoperative fentanyl, atracurium, and isoflurane consumption, operative time, postoperative analgesia, duration of anesthesia, and side-effects such as nausea, vomiting, and shivering. Results: There were no significant differences between the 2 groups as regards to age, weight, duration of surgery, and the duration of anesthesia. There were no significant differences in the time of the first analgesic request in both groups. Pain score was statistically insignificant between both groups. The incidences of postoperative nausea, vomiting and shivering were more in group II than group I. Conclusion: Preoperative administration of a single dose of magnesium sulfate (50 mg/kg) versus preoperative ultrasound guided bilateral transversus abdominis plane block in patients undergoing colorectal surgery was associated in both groups with reduction in the analgesic requirements postoperatively, with less postoperative nausea, vomiting and shivering in the magnesium sulfate group.