歯学ジャーナル
オープンアクセス

概要

The Role of PI3K Isoforms in Ocular Angiogenesis

Dongwei Lai, Baiqi Liu, Linqing Xiong, Yiwei Yin, Xiaobo Xia, Wenyi Wu

Ocular angiogenesis is an important contributor to many vision-decreasing diseases, such as retinopathy of prematurity, proliferative diabetic retinopathy, as well as age-related macular degeneration. Understanding the molecular mechanism of angiogenesis has advanced the development of effective medicine in preventing ocular neovascularization. Phosphoinositide 3 kinases (PI3Ks), a main downstream of growth factors, are a family of lipases that are evolutionarily conserved in their ability to regulate cell growth and survival as well as migration and metabolism. Much evidence showed that it also plays a significant role in angiogenesis. Here, we review the distinct functions of class I PI3Ks in the canonical angiogenic pathway and its potential mechanism as a novel therapeutic target in ocular pathological angiogenesis.