select ad.sno,ad.journal,ad.title,ad.author_names,ad.abstract,ad.abstractlink,j.j_name,vi.* from articles_data ad left join journals j on j.journal=ad.journal left join vol_issues vi on vi.issue_id_en=ad.issue_id where ad.sno_en='49580' and ad.lang_id='6' and j.lang_id='6' and vi.lang_id='6' Ultrasound-mediated Microbubble Destruction Promotes Bone Ma | 49580
プロバイオティクスと健康に関するジャーナル

プロバイオティクスと健康に関するジャーナル
オープンアクセス

ISSN: 2155-9880

概要

Ultrasound-mediated Microbubble Destruction Promotes Bone Marrow Mesenchymal Stem Cell Transplantation for Myocardial Infarction Therapy

Fuchao Yu, Jinyu Li, Zhuo Xu, Zhouzhou Lu, Xiaohui Zhang, Dan Li, Jiayi Tong

The study was designed to investigate whether ultrasound-mediated microbubble destruction can enhance the transplantation of bone marrow mesenchymal stem cells (BMSCs) for myocardial infarction therapy, twenty myocardial infarction pigs were assigned into the ultrasound microbubble destruction group (n=12, Sonovue were infused into coronary artery with ultrasonic radiation, then BMSCs were injected into infarction region) and the cell control group (n=8, only subjected to BMSCs treatment). The increase of left ventricular ejection fraction was larger in the ultrasound microbubble destruction group (P<0.01), and more Prussian blue-positive cells and higher density of heart muscle capillary in the peripheral infarct regions were found (P<0.01). Prussian blue-positive cells were differentiated into new vascular endothelial cells in two cases, among which the gaps were widened in the microbubble destruction group. Our study first time testifies in pig models that ultrasound-mediated microbubble destruction promotes BMSC transplantation for myocardial infarction therapy.

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