HIV: 現在の研究
オープンアクセス

概要

Virus Inuced Cell Death in Pathogenic Process

Paulo Sangalo

An essential cell death process that aids in the preservation of equilibrium in living systems is the apoptotic pathway. Apoptosis variants have, however, been connected to a wide range of illnesses, including cancer and recurrent infections. Because of the steady depletion of CD4+ T cells caused by the HIV infection, mortality and morbidity have increased globally. Both the intrinsic and extrinsic apoptotic pathways' activation and mediation are essential for HIV pathogenesis and intracellular survival. Since this can open up new avenues for therapeutic intervention and control, a thorough molecular understanding of how apoptosis is triggered and controlled in HIV-mediated CD4+ T cell depletion is crucial.