医療安全と世界の健康
オープンアクセス

概要

グローバル毒性学 2020: アトラジンは、発情周期の排卵期に牛の子宮頸管の機能を損なう可能性があるか? ミハル H ブロベル、動物生殖・食品研究所、ポーランド

ミハル・H・ヴロベル

Atrazine, which belongs to triazine class of herbicides, remains a staple of the American and Indian agriculture, while is subjected to strict regulation that effectively prevents its use in Europe. It was previously shown that atrazine increased the secretion of ovarian oxytocin (OT), which is a potent uterotonic agent. However, atrazine directly inhibit the myometrial contractions in cows. Hence, the aim of this study was to determine its effect on the motoric function of bovine cervix.

Cervical strips or cells from cows at 18-20 days of oestrous cycle were incubated (24-72h) with atrazine (10 ng/ml). The used dose of atrazine, which was chosen according to the our previous studies, has exerted any cytotoxic effect. However, it increased the force of cervical contractions and it has not affected the level of myosin light chain kinase (MLCK). While atrazine decreased the secretion of PGE2, amount of gap junction proteins (GAPs) and the second messengers (DAG, IP3), which are involved in transmission of signal to contraction.  Atrazine showed direct stimulation of the force of cervical contractions and inhibition of cellular signalling. Hence, it has potential to impair the function of cervix, which can be followed by failures in beginning of gestation.