医薬品設計: オープンアクセス
オープンアクセス

概要

The New Acetaminophen Drug in the Form of Nano-Organometallic Compounds as a Bright Future for Antimicrobial Therapy

Abdou saad El-Tabl, Moshira Mohamed Abd El-Wahed, Ahmed M. Ashour1, Reham Ali S. Ahmed

New nano-organometallic compounds analogue to acetaminophen drug containing the same functional groups (hydroxyl (OH), amide (HN-CO-CH₃) and aromatic group (benzene ring)) have been prepared. They were characterized using elemental and advanced spectral techniques such as infrared and ultraviolet spectra, proton nuclear magnetic resonance, mass spectra, electron spin resonance and electron microscope as well as magnetism, conductivity and thermal analysis. The spectral and thermal data showed octahedral structure with stability of these compounds up to 50°C. The biological activity of the compounds against gram (+ve), gram (-ve) bacteria and fungi were carried out. Due to the difficulty of testing these compounds on animal viruses in our lab, we applied on plant viruses and impressive results were also obtained and this gave us hope for applying it to human viruses for example corona virus. The order of activity was, for gram +ve (staphylococcus aureus): Cd(II) compound (3)>Co(II) compound (6)>Ampicllin>Ni(II) compound (4)>Cu(II) compound (5)>Cu(II) compound (2)>Zn(II) compound (7)>acetaminophen=ligand (organic compound). For gram –ve Escherichia coli, the order was Cd(II) compound (3)>Ampicllin> Co(II) compound (6)> Ni(II) compound (4)>Cu(II) compound (5)>Cu(II) compound (2)>Zn(II) compound (7)>acetaminophen=ligand (organic compound). For (Aspergillus flavus), the order was Cd(II) compound (3)>Amphotericin B>acetaminophen=ligand (organic compound)=Cu(II) compound (2)=Ni(II) compound (4)=Cu(II) compound (5)=Co(II) compound (6)=Zn(II) compound (7) and for Candida albicans, the order was Cd(II) compound (3)>Amphotericin>Ni(II) compound (4)>Co(II) compound (6)>Cu(II) compound (5)>Cu(II) compound (2)>acetaminophen=ligand (organic compound)=Zn(II) compound (7). The above results showed Cd(II) compound (3) is the highest potent against gram (+ve), gram (-ve) and fungi compared to standard drugs. Cytotoxic effect of this compound was carried out on experimental rats and no toxic effects were observed (six months) on the functions of all organs using clinical analyses.