有機化学: 現在の研究
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概要

Impact of Palm Kernel Oil (PKO) Biodiesel-Contaminated Catfish on Hepatic Function of Rat

Adeyemi Olalekan

The purpose of the present study was to assess the effects of consumption of catfish (Clarias gariepinus) exposed to palm kernel oil (PKO) biodiesel on functions and oxidative status of liver of albino rat. The author measured the responses of growth performance (average daily weight gain, feed conversion ratio, body weight, and relative liver weight), oxidative stress, and indices of liver functions of rat placed on feed formulated with catfish exposed to borehole water mixed with different concentrations of PKO biodiesel ( 0 % w/v, 0.1 % w/v, 0.25 % w/v). The results showed that fish exposed to PKO biodiesel had no effect on relative liver weight, but average body weight was significantly reduced, serum levels of total and direct bilirubin were significantly elevated while those of bilirubin and globulin were significantly reduced. However, specific activities of catalase (CAT), superoxide dismutase (SOD) and glutathione-s-transferase (GST) of serum of rats fed with catfish exposed to lower concentration of PKO biodiesel (BD 0.1) were significantly higher than those of rats fed with catfish exposed to higher concentration of PKO biodiesel (BD 0.25) (p<0.05) while both are significantly lower than that of the control rats (p<0.05). Serum level of MDA in test rats increased significantly (p<0.05) as the concentration of PKO biodiesel increased. The data clearly demonstrate that consumption of catfish exposed to PKO biodiesel can result in liver dysfunction at a degree not dependent on concentration of PKO biodiesel by a mechanism of oxidative stress which is dependent on the concentration of PKO biodiesel.