解剖学と生理学: 現在の研究
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概要

A Review on Genetics of Intervertebral Disc Disease in Indian Perspectives

1Ravichandran Doraiswamy1*, Tamara Nancoo2, Andre Yusuff3, Kandamaran Krishnamurthy4, Pritika Kandamaran5, Harshini Revanaru6, Gottam Vinay6, Artham Yashwanth6

Degeneration of the Intervertebral Disc (IDD) is caused by a range of genetic variations. Although some have been reliably discovered in either phenotype, few are shared with polymorphisms leading to back pain. To properly understand the high heritability and how the genetic variations affect cell biology to cause IDD, more study is needed. It has long been recognized that IDD is largely heritable. New polymorphisms in a number of genes that increase the incidence of IDD and back pain have been found in recent study, in part due to the availability of agnostic approaches like genome-wide association analyses. The goal of this review is to highlight recent developments in our knowledge of the genetic causes of IDD.