リウマチ学: 現在の研究
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概要

Antiphospholipid Syndrome, Factor V Leiden Mutation and Chronic Viral Hepatitis B: A Case with Extremely Numerous Recurrent Miscarriage

Gokhan Sargin, Taskin Senturk, Irfan Yavasoglu and Adil Coskun

The Antiphospholipid Syndrome (APS) is a prothrombotic disorder associated with autoantibodies, and used ‘Sapporo criteria’ or revised ‘Sydney criteria’ for classification. APS may be with primary or secondary to systemic lupus erythematosus, or infectious diseases. Viral infections, especially HCV may lead chronic antigenic stimulation, and induce autoimmunity and antiphospholipid antibodies due to molecular mimicking. Such as APL, factor V Leiden mutation also lead to thrombotic events. These two disorders are also reported rarely in literature. Our aim is to present 37-year-old female patient who had medical history of extremely numerous recurrent miscarriage with combination of antiphospholipid syndrome, factor V Leiden mutation and chronic viral hepatitis.