血管学: オープンアクセス
オープンアクセス

概要

Association of Brachial Artery Measures with Estimated GFR>60 mL/min/1.73 m2 in a Cross-Sectional Study of the Community-Based Women

Kazumi Fujioka*, Minoru Oishi, Tomohiro Nakayama and Akira Fujioka

Objective: The purpose of this study is to estimate whether early decline in kidney disease is correlated with brachial artery measures as surrogate markers of the endothelial function in community-based women. Methods: We studied 36 women with estimated glomerular filtration rate (eGFR)>60 mL/min/1.73 m2 in community-based population women were enrolled in this study. Brachial artery measures including Flow-Mediated Vasodilation (FMD), Nitroglycerin-Mediated Vasodilation (NMD), Brachial Artery Diameter (BAD), FMD/NMD ratio and Post-Nitroglycerin Brachial Artery Diameter (P-NTGD) examinations were measured in all subjects by using brachial artery ultrasonography. The eGFR was calculated using the Japanese GFR inference formula, which was developed by the Japanese Society of Nephrology. Results: There was significantly positive correlation between eGFR and FMD (r=0.348, p=0.041), positive correlation between eGFR and FMD/NMD ratio (r=0.471, p=0.004) and negative correlation between eGFR and P-NTGD (r=-0.405, p=0.016) were recognized. Negative correlation between Serum Uric Acid (SUA) and eGFR (r=-0.335, p=0.049) and negative correlation between FMD and SUA (r=-0.34, p=0.045) were also demonstrated. Conclusion: Mild renal dysfunction with eGFR>60 mL/min/1.73 m2 was associated with endothelial dysfunction in women. The cardio-renal interrelationship may be also suggested under mild renal dysfunction. It can be suggested that mild renal dysfunction might be a cardiovascular risk factor in women. Though it should not be distinctly stated just based on the results of the study. Keywords: Estimated glomerular filtration rate; Flow-mediated vasodilation; Endothelial dysfunction; Cardio-renal interrelationship; Mild renal dysfunction