細胞および発生生物学
オープンアクセス

概要

Balanced Chromatin within the Germ (Human) Line

Sunayana Varma

Poised (bivalent) chromatin is characterized by the concurrent nearness of histone adjustments related with both quality enactment and suppression. This epigenetic include was to begin with watched at promoters of lineagespecific administrative qualities in embryonic stem cells in culture. More later work has appeared that, in vivo, mammalian germ cells keep up balanced chromatin at promoters of numerous qualities that direct substantial advancement, which they hold this state from fetal stages through meiosis and gametogenesis. We hypothesize that the balanced chromatin state is fundamental for germ cell personality and work. We propose three parts for poised chromatin within the mammalian germ line: anticipation of DNA methylation, upkeep of germ cell character and preparation for totipotency. We talk about these parts within the setting of as of late proposed models for germline power and epigenetic legacy.