遺伝症候群と遺伝子治療のジャーナル
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概要

Novel Inflammasomes and Type II Diabetes, Intestinal Inflammation and Psoriasis as Newly Inflammasome-Related Diseases

Michael C. Heymann and Sigrun R. Hofmann

Inflammasomes are multiprotein complexes representing an activating platform for caspase-1. This enzyme processes the cytokines IL-1β, IL-18 and others into their bioactive variants leading to an inflammatory cascade. Mutations responsible for defects in inflammasome regulation cause severe autoinflammatory disorders.
 
This review provides a short summary of new insights in the autoinflammatory field including the association of inflammasomes to diabetes, intestinal inflammation as well as psoriasis and communicates the ideas of two novel inflammasomes, recently discovered.