内分泌学とメタボリックシンドローム
オープンアクセス

概要

Recent Progress in Genetic Polymorphisms and Diabetic Retinopathy (DR) in Type 1 Diabetes Mellitus (T1DM)

Qi Xu, Shuai Guo and Xiaolin Xiao

Type 1 diabetes (T1D) is one of the major health burdens worldwide. Diabetes induced diabetic retinopathy (DR) is the most common diabetic eye disease and the leading cause of preventable blindness in working-age adult. Several genetic loci have recently been reported to contribute to the susceptibility of type 1 diabetes induced DR. In order to further understand the genetic influence on the risk of DR in T1D patients, we reviewed and collected the articles from PUBMED for genes that reported by recent genetic studies. At the conclusion of our search, we summarized the publications about relative genetic association studies and summarized the candidate genes, which might relate with DR in T1D patients. Despite the findings of this and other similar, contemporary research projects, many of the special details and underlying mechanisms in this field of study are still, to a great extent, unknown. As a result, future studies are needed to gain a full appreciation regarding the identification of high DR risk in T1D patients.