プロバイオティクスと健康に関するジャーナル
オープンアクセス

概要

Challenges and Strategies in Anticoagulation Management for DOAC-Treated Patients Undergoing Emergency Cardiac and Aortic Surgeries

Kohei Nagashima*

Effective anticoagulation management with heparin is critical during Cardiopulmonary Bypass (CPB) in emergency cardiac and aortic surgeries. However, in patients using Direct Oral Anticoagulants (DOACs), the administration of Andexanet alfa can induce heparin resistance, complicating management. This study aimed to investigate the mechanisms underlying heparin resistance induced by Andexanet alfa, as well as explore optimal hemostatic strategies for such patients during emergency cardiac and aortic surgeries.