リウマチ学: 現在の研究
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概要

New Biomarker of Systemic Lupus Erythematosus for CXCL13

Jinfan Li Li

Various investigations throughout the most recent decade have connected the B cell-drawing in chemokine CXC ligand 13 (CXCL13) to the immune system illness foundational Lupus Erythematosus (SLE). A pathogenetic part of this chemokine for sickness sign in SLE was depicted at first in mouse models for SLE. Instruments of CXCL13 activities were likewise distinguished in SLE patients. In addition, different clinical examinations have distinguished CXCL13 serum levels as a helpful biomarker in patients with SLE of various nationalities for illness action. Moreover, CXCL13 is by all accounts a promising marker for the determination of lupus nephritis, one of the most extreme difficulties of SLE. Notwithstanding, its precise spot inside the components that lead to SLE stays to be characterized. Further exploration is expected to determine more subtleties of the pathomechanism and the flagging pathway of CXCL13 in SLE. Impeding CXCL13 or the sign pathways of CXCL13 is viewed as a promising helpful methodology for SLE and will be tended to sooner rather than later. This audit sums up all papers that connected CXCL13 to SLE and features its significance in the pathogenesis and determination of SLE.