周術期医学ジャーナル
オープンアクセス

概要

Role of Pennisetum Glaucum Extract (PGE) on Thrombotic Disorder

Devaraja Sannaningaiah

Thrombotic Disorders (TD) increase the risk of cardiovascular/cerebrovascular complications and represent a major health problem worldwide. Although, anticoagulant, antiplatelet and fibrinolytic agents have been widely used, their life threatening side effects limits their usage. The objective of this study is to evaluate the protective role of Pennisetum Glaucum Extract (PGE) on thrombotic disorder. Both in-vitro and in-vivo experiments were carried out to establish the anticoagulant, antiplatelet and antioxidant properties of PGE. The parameters such as plasma recalcification time, Prothrombin Time (PT), Activated Partial Thromboplastin Time (APTT) and agonist induced platelet aggregation assays were employed. PGE was also analysed for its efficacy on oxidative stress as well.