小児科と治療学
オープンアクセス

概要

Pediatric Kidney Transplantation-A Mini-Review about Etiology, Complications and Graft Survival

Natália Dalsenter Avilez1, Ana Beatriz Pereira de Souza1, Di Domenico BR1, Liliane Cury Prates2, Marilda Mazzali3, Marcelo Lopes de Lima1*

Kidney transplantation is the standard of care for children in end-stage kidney disease. Despite advances, it is still a challenge. Since this is a relatively infrequent surgery and the complexity to perform studies in children, it is rare to find large clinical trials in this area. The aim of this mini-review is to compile the results of published studies to obtain a global understanding of the current pediatric transplant situation. Congenital Anomalies of the Kidneys and Urinary Tract (CAKUT) is the main cause of chronic kidney disease in children, and non-CAKUT causes increased frequency with age. Regarding graft loss, surgical complications are still the main cause of which thrombosis is the most common. Another issue is non-adherence to medications, especially within teenagers. Considering the difficulties of large-scale prospective studies in this area, continued collaboration between reference centers is essential to address ongoing challenges and improve outcomes in this patient population. Keywords: Pediatric kidney transplant; Kidney transplantation; Surgical complications; Graft survival; Graft thrombosis